张东玲

首席专家

张东玲，女，博士，副教授，博士生导师，福建省C类人才，福建省科技特派员，兼企业技术顾问。

Emai: 342312933@qq.com

QQ: 342312933

二、研究方向

1. 鱼类遗传育种：利用多种组学方法对鱼类多种性状进行良种选育。

2. 鱼类基因组学：组装鱼类基因组，挖掘功能基因。

3. 益生菌：利用多种方法构建或分离益生菌并应用到生产。

三、近五年主持的课题

1. 国家自然科学基金面上项目，32172964，大黄鱼抗烂身病性状的遗传解析，2022.01-2025.12，资助金额：75.4万元，在研，主持。

2. 福建省种业创新与产业化工程项目，斑鳜和黑脊倒刺鲃种业创新与产业化开发，2022.08-2025.08，资助金额：90万，在研，主持。

3. 福建省自然科学基金重点项目，2022J02042, 大黄鱼抗盾纤毛虫病性状的遗传基础解析，2022.08-2025.02，资助金额：20万，在研，主持。

4. 厦门市科技局-产学研后补助项目，2024CXY0320，海洋生物活性肽抗多种副溶血弧菌活性研究与开发，2024.10-2027.10，资助金额：16万，在研，主持.

5. 企业联合横向，生产尾水处理益生菌的研发和应用，2024.04-2027.04，资助金额：50万，在研，主持。

6. 企业联合横向，大蒜E素（乙蒜素）在自然海区抗大黄鱼内脏白点病和盾纤毛虫病的应用技术研究，2024.06-2026.12，资助金额：21万，在研，主持。

7. 企业联合横向，海洋生物活性肽抗多种副溶血弧菌活性研究与开发，2023.08-2028.08，资助金额：50万，在研，主持。

8. 国家海洋水产种质资源库建设，每年资助，2019.01-至今，资助金额：5万，在研，主持。

9. 企业联合横向，大蒜E素（乙蒜素）对大黄鱼内脏白点病防治效果研究，资助金额：5万，2023.07-2025.03，在研，主持。

10. 福建省自然科学基金面上项目，2019J01692，适应无鱼粉鱼油饲料大黄鱼分子标记辅助选育的基础研究，2019.05-2022.06，资助金额：10万，结题，主持。

四、代表论著

1. Yan Chunmei, Chen meiling, Jin Jian, Liu Xiande, Wang Zhiyong, Luo Yongju, Zhang Dongling(通讯作者）*. Bacillus subtilis 2118 exhibits bactericidal activity due to an inserted fish cDNA library. Aquaculture, 2024, 593:741300.

2. Tang Xin, Xiao Zhiqun,Chen meiling, Zhu Xingcheng,Wang Zhiyong, Zhang Dongling(通讯作者）*. A prototype galectin-1 (also known as galecin-2) from large yellow croaker (Larimichthys crocea): Molecular and function study. Fish & Shellfish Immunology, 2024,145:109314.

3. Chen meiling, Xiao Zhiqun, Yan Chunmei, Tang Xin, Ming Fang, Wang Zhiyong, Zhang Dongling(通讯作者）*. Centrosomal protein of 192 kDa (Cep192) fragment possesses bactericidal and parasiticidal activities in Larimichthys crocea. International Journal of Biological Macromolecules, 2024, 254:127744.

4. Chen meiling, Lin Nengfeng, Liu Xiande, Tang Xin, Wang Zhiyong, Zhang Dongling(通讯作者）*. A novel antimicrobial peptide screened by a Bacillus subtilis expression system, derived from Larimichthys crocea Ferritin H, exerting bactericidal and parasiticidal activities. Frontiers in immunology, 2023, 1168517.

5. Tang Xin, Zhu Xingcheng, Liu Xiande, Wang Zhiyong, Zhang Dongling(通讯作者）*. A unique C-type lectin, Ladderlectin, from large yellow croaker (Larimichthys crocea) is involved in bacterial cell membrane damage. Fish & Shellfish Immunology, 2023, 136:108744.

6. Li Zeyu, Fang Ming, Tang Xin, Zhang Dongling(通讯作者）*, Wang Zhiyong*. Disentangling genetic variation for endurance and resistance to visceral white-nodules disease in large yellow croaker (Larimichthys crocea) using genome information. Aquaculture, 2023, 564:739045.

7. Tang Xin, Liu Xiande, Wang Zhiyong, Chen meiling, Zhang Dongling(通讯作者）*. Molecular Characterization, Expression, and Regulatory Signal Pathway Analysis of Inflammasome Component Apoptosis-Associated Speck-like Protein Containing a CARD Domain (ASC) in Large Yellow Croaker (Larimichthys crocea). International Journal of Molecular Sciences, 2023, 24:2175.  

8. Tang Xin, Wang Zhiyong, Jiang Dan, Chen Meiling, Zhang Dongling(通讯作者）*. Expression profile, subcellular localization of MARCH4 and transcriptome analysis of its potential regulatory signaling pathway in large yellow croaker (Larimichthys crocea). Fish & Shellfish Immunology, 2022, 52:273-282.

9. Zhang ZhenXi, Wang Zhiyong, Fang Ming, Ye Kun, Tang Xin, Zhang Dongling(通讯作者）*. Genome-wide association analysis on host resistance against the rotten body disease in a naturally infected population of large yellow croaker Larimichthys crocea. Aquaculture, 2022, 548:737615.

10. Zhang Dongling, Lv Chang Huan, Yu Da Hui, Wang Zhi Yong*. Characterization and functional analysis of a galectin-9 protein in large yellow croaker Larimichthys crocea. Fish & Shellfish Immunology, 2016, 52:167-178.

11. Lv Chang Huan#, Zhang Dongling#（共同第一作者）, Wang Zhi Yong*. A novel C-type lectin, Nattectin-like protein, with a wide range of bacterial agglutination activity in large yellow croaker Larimichthys crocea, Fish and Shellfish Immunology, 2016, 50:231-241.

12. Zhang Dongling, Da Hui Yu, Jian Chen, Zhi Yong Wang*. Co-expression and interaction suggest TBK1 can be regulated by Nrdp1 in response to immune stimulation in large yellow croaker Larimichthys crocea, Fish and Shellfish Immunology, 2015, 46:745- 752.

13. Zhang Dongling, Da Hui Yu, Jian Chen, Zhi Yong Wang*. Characterization and expression analysis of BCA2 gene in large yellow croaker, Larimichthys crocea. Fish and Shellfish Immunology, 2015, 46:543-549.

14. Zhang Dongling, Fang Han, Da Hui Yu, Shi Jun Xiao, Ming Yun Li, Jian Chen, Zhi Yong Wang*.Characterization of E3 ubiquitin ligase neuregulin receptor degradation protein-1 (Nrdp1) in the large yellow croaker (Larimichthys crocea) and its immune responses to Cryptocaryon irritans. Gene, 2015, 556:98-105.

15. Zhang Dongling, Yu Da Hui, Chen Jian, Wang Zhi Yong*. Co-expression of march5b and tlr7 in large yellow croaker Larimichthys crocea in response to Cryptocaryon irritans infection, Journal of Fish Biology, 2015, 87:360-70.

16. XuHao#, Zhang Dong